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November 12, 2025Human Reproduction

The contribution of single-cell omics technologies to improve knowledge on human early embryo development

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Authors

OGOcéane GirardEMEva MoinardLDLaurent David

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Overview

Review highlights single-cell omics advances in embryonic genome activation and lineage specification, indicating improved knowledge on embryonic development stages.

Key Points

  • The central aim is to review how single-cell omics technologies contribute to understanding human early embryo development.
  • Review of discoveries in embryonic development facilitated by single-cell omics technologies.
  • Incorporation of transcriptomics, epigenomics, and proteomics data to analyze embryonic development stages.
  • Examination of the progression from fertilization to gastrulation.
  • Clarification of cellular heterogeneity and spatial organization in early development stages.
  • Delineation of the trophectoderm, epiblast, and hypoblast lineages.
  • Identification of rare post-implantation populations like primordial germ cells and amnion.

Cite This Study

Girard et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc3555bbhttps://doi.org/10.1093/humrep/deaf206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The multi-omics regulatory landscape of human early embryogenesis2026
  2. 2Single Cell RNA Sequencing and Its Impact on Understanding Human Embryo Development2025
  3. 3O-172 Live imaging reveals key events in preimplantation embryo development2024
  4. 4Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation2024 · 4 citations
  5. 5Omics approaches in embryonic microenvironment research: a narrative review2026