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May 9, 2026Cellular and Molecular Life SciencesOpen Access

The multi-omics regulatory landscape of human early embryogenesis

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Authors

YDYi‐Wen DingAnhui University of Traditional Chinese MedicineLZLiquan ZhouHuazhong University of Science and TechnologyYGYa-xin GuoTongji Hospital

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Implication

Review summarizes regulatory mechanisms in early human embryogenesis, indicating importance for reproductive outcomes.

Key Points

  • This review aims to elucidate the regulatory networks involved in human early embryogenesis and their implications for reproductive health.
  • Systematic profiling of transcriptomics, epigenomics, proteomics, and metabolomics using ultra-low-input samples.
  • Comparison of regulatory mechanisms between human and mouse embryos.
  • Analysis of various embryo types including parthenogenetic, androgenetic, tripronuclear, and normal bipronuclear.
  • Identified key multi-omics findings that influence development and quality of human embryos.
  • Synthesis of complex interactions between parental genomes affecting cell fate decisions.
  • Established a framework for better modeling human embryogenesis relevant to reproductive technology.

Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69fececcb9154b0b8287618fhttps://doi.org/10.1007/s00018-026-06231-z
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  1. 1Insights into epigenetic patterns in mammalian early embryos2020 · 227 citations
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  3. 3Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation2022 · 201 citations