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November 12, 2025eLifeOpen Access

Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

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Authors

PDPriyojit DasRMRebeca San MartinTHTian Hong

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Overview

Analysis reveals how 3D genome organization affects organotropism and cell fate in breast cancer metastatic traits.

Key Points

  • To explore the relationship between 3D genome organization and organ-specific metastatic traits in breast cancer.
  • Comparative analysis of genomic data from localized and lung metastatic breast cancer cells
  • Investigation of chromosome architecture changes
  • Characterization of compartment switches in relation to epithelial and mesenchymal statuses
  • Identified significant trends in 3D genome organization related to organotropism
  • Found distinct compartment signatures for epithelial and mesenchymal cells
  • Gene expression changes correspond with organ-permissive 3D genome changes

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc3557f2https://doi.org/10.7554/elife.103697.3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism2025
  2. 2Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism2024
  3. 3Loss of multilevel 3D genome organization during breast cancer progression2025
  4. 4Single-cell decoding of breast cancer organotropism: ecosystem mapping for precision therapy2026
  5. 5Abstract 6662: Spatial genomics reveals microenvironmental programs associated with organ-specific metastatic propensity in prostate cancer2026