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October 11, 2025Genome ResearchOpen Access

Loss of multilevel 3D genome organization during breast cancer progression

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Authors

RRRoberto RossiniMOMohammadsaleh OshaghiUniversity of OsloMNMaxim NekrasovAustralian National University

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Overview

Analysis uncovers alterations in chromatin structure and oncogenic gene expression in breast cancer, suggesting critical genome organization loss.

Key Points

  • Significant loss of 3D genome organization correlates with oncogenic gene expression changes during breast cancer progression.
  • Analysis showed that TAD-TAD interactions and compartmentalization are restructured, impacting breast cancer development.
  • The study used Hi-C data and epigenomic marks in an in vitro model to explore 3D chromatin structure during cancer progression.
  • Findings reveal novel relationships between structural genomic variants and oncogenesis, notably involving the MYC oncogene.

Cite This Study

Rossini et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d9ba7d64b6fc132d80https://doi.org/10.1101/gr.280791.125
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