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July 29, 2026Cell Communication and SignalingOpen Access

3D chromatin structure remodelling in cancer

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Authors

YLYing LiuMWMinghua Wu

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Overview

Overview of 3D chromatin changes influencing tumorigenesis and potential therapeutic strategies.

Key Points

  • This research aims to explore the role of 3D chromatin structure alterations in cancer development and potential therapies.
  • Overview of hierarchical alterations in cancer 3D chromatin structure
  • Review of detection technologies and emerging therapeutic strategies
  • Integration of multi-omics data for developing targeted drugs
  • Altered 3D chromatin structure is linked to tumor phenotypic plasticity
  • High-order chromatin organization change leads to oncogene activation and tumor suppressor gene silencing
  • Unique 3D chromatin patterns may serve as novel biomarkers for cancer diagnosis and treatment

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2bcc8da07d9defa6869https://doi.org/10.1186/s12964-026-03097-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies2026
  2. 2The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options2026
  3. 3Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics2026
  4. 4Loss of multilevel 3D genome organization during breast cancer progression2025
  5. 5Three‐dimensional chromatin landscapes in somatotroph tumour2024 · 3 citations