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June 7, 2026Experimental & Molecular MedicineOpen Access

3D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies

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Authors

SJSunyoung JangKYKyung Hyun Yoo

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Overview

This review explores 3D genome architecture alterations in cancer, linking structural changes to therapeutic strategies.

Key Points

  • The review aims to synthesize insights into how 3D chromatin structure is altered in cancer and its implications for therapy.
  • Discusses mechanisms of dysregulation caused by alterations in DNA regulatory elements and architectural proteins.
  • Evaluates high-resolution genome conformation technologies like Hi-C and HiChIP to analyze cancer progression.
  • Reviews emerging therapeutic strategies targeting 3D genome architecture.
  • Widespread spatial reorganization across various tumour types was uncovered through advanced genomic technologies.
  • Structural perturbations activate oncogenic enhancers and promote inappropriate promoter–enhancer communication.
  • Emerging strategies like epigenetic modulators show promise in targeting 3D chromatin dysregulation.

Cite This Study

Jang et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d2cehttps://doi.org/10.1038/s12276-026-01748-6
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  1. 13D chromatin structure remodelling in cancer2026
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  3. 3The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options2026
  4. 4Navigating the 3D genome at single-cell resolution: techniques, computation, and mechanistic landscapes.2025 · 2 citations
  5. 5Loss of multilevel 3D genome organization during breast cancer progression2025