Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Hui-Bin Xie; Dan-Ping Li; Yu Cao; Ya-feng Lv; Hongyan Wu; Chunyu Cao

doi:10.1016/j.molimm.2025.11.001

November 12, 2025Molecular ImmunologyOpen Access

Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

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Key Points

Explore the therapeutic potential of AAV8-mediated IL-17RA gene delivery in psoriasis treatment.
Utilized an imiquimod-induced mouse model of psoriasis.
Administered AAV8-mediated IL-17RA extracellular domain gene delivery.
Measured cutaneous inflammation and cytokine levels post-treatment.
Gene delivery significantly blocked cutaneous inflammation.
Observed reductions in the overexpression of inflammatory cytokines.

Implication

AAV8-mediated IL-17RA gene delivery reduces inflammatory cytokines in mice with psoriasis, suggesting new treatment avenues.

Abstract

AAV8-mediated IL-17RA(ECD) gene delivery effectively blocks cutaneous inflammation and attenuates inflammatory cytokines overexpression in an IMQ-induced mouse model of psoriasis, highlighting its therapeutic potential for chronic inflammatory skin diseases.

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Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc35585a https://doi.org/10.1016/j.molimm.2025.11.001

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Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Key Points

Implication

Abstract

Discussion

Cite This Study

Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.

Key Points

Implication

Abstract

Discussion

Cite This Study

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