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November 12, 2025CancersOpen Access

Emerging Diagnostics and Therapies in Neuroendocrine Neoplasms: A Critical Review

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Authors

JHJorge H. Hernandez-FelixMMMónica Isabel Meneses MedinaRRRachel Riechelmann

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Overview

Critical review highlights systemic therapies and diagnostic improvements for neuroendocrine neoplasms, suggesting ongoing developments.

Key Points

  • This review aims to summarize recent advances in diagnostics and therapies for neuroendocrine neoplasms.
  • Critical review of recent evidence until mid-2025
  • Evaluation of diagnostic tools including somatostatin-receptor PET/CT and FDG PET
  • Assessment of systemic therapies like cabozantinib and radioligand therapy
  • Somatostatin-receptor PET/CT has replaced older scintigraphy
  • Cabozantinib improves progression-free survival after prior therapy
  • Radioligand therapy is increasingly used in early receptor-positive disease
  • Immunotherapy is available for defined subsets including high-grade neoplasms

Cite This Study

Hernandez-Felix et al. (2025) studied this question.

synapsesocial.com/papers/692523d9c0ce034ddc355897https://doi.org/10.3390/cancers17223632
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Theranostics in Neuroendocrine Neoplasms: The Multifaceted Aspects Integrating Imaging, Therapy, and Dosimetry.2026
  2. 2Emerging Treatment Options for Neuroendocrine Neoplasms of Unknown Primary Origin: Current Evidence and Future Perspectives2024 · 5 citations
  3. 3Theranostics in Neuroendocrine Tumors2024 · 12 citations
  4. 4Theranostics in Pancreatic Neuroendocrine Neoplasms: From Molecular Imaging to Personalized Radionuclide Therapy2026
  5. 5Biochemical Markers for Neuroendocrine Tumors: Traditional Circulating Markers and Recent Development—A Comprehensive Review2024 · 13 citations