Genome-wide screen identifies host factors in yeast, showing L-A virus benefits its host under stress, suggesting mutualism.
Our findings uncover a previously unrecognized virus-host mutualism, wherein L-A benefits its host under environmental stress. These results not only expand our understanding of persistent viral infections in eukaryotes but also challenge the canonical view of viruses as purely parasitic, offering new insights into virus-host co-evolution and endogenous viral persistence.
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Hsiao et al. (2025) studied this question.
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