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November 11, 2025Langmuir

Electrochemiluminescent Enantiodiscrimination on Chiral Engineered l -His-ZIF8

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Authors

HWHuimin WangGWGuangxin WangRLRuoxi Liu

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Overview

Novel electrochemiluminescence platform demonstrates enantioselective recognition of amino acids, indicating advancements in chiral discrimination.

Key Points

  • This research aims to develop a cost-effective electrochemiluminescent platform for chiral recognition of amino acids.
  • Constructed an enantioselective platform using l-histidine-functionalized zeolitic imidazolate frameworks (l-His-ZIF8)
  • Characterized the chiral material and tested its response on six amino acids
  • Used Ru(bpy)3^2+ as a luminophore for electrochemiluminescence measurements.
  • Achieved a distinct ECL signal ratio for d-Cys over l-Cys of 3.3 at 1 mM
  • Obtained a detection limit of approximately 0.193 mM for Cys enantiomers
  • Observed a stronger ECL response for l-Trp compared to d-Trp with a ratio of 2.4 at 1 mM.
  • Confirmed the preferential binding of l-His-ZIF8 with specific enantiomers led to enhanced ECL.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69252e9ec0ce034ddc3564a4https://doi.org/10.1021/acs.langmuir.5c03908
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