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November 11, 2025Angewandte Chemie International EditionOpen Access

On the Nature of Improper Hydrogen Bonding in RCH 2 F and RCHF 2 Motifs

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Authors

BPBruno A PiscelliMBMichael BuhlRCRodrigo A. Cormanich

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Overview

Computational analysis uncovers hydrogen bonding dynamics in fluorinated groups, suggesting new insights into electrostatic interactions.

Key Points

  • Hydrogen bonds identified in fluorinated substituents are weakened by increased fluorination, suggesting dynamic interactions.
  • Electrostatic interaction plays a dominant role in bonding scenarios involving chloride ions and fluorinated carbons.
  • The study offers insights into non-classical hydrogen bonding behavior, particularly in alicyclic structures incorporating fluorinated motifs.
  • Findings indicate RNA interactions between organo-fluoro components and chloride ions, highlighting novel application potential.

Cite This Study

Piscelli et al. (2025) studied this question.

synapsesocial.com/papers/69252e9ec0ce034ddc356537https://doi.org/10.1002/anie.202518500
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