Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 24, 2025

The influence of C-F⋯H-X hydrogen-bonding interactions on the reactivity and selectivity of organic reactions.

View Full Paper
Ask AI
Bookmark
Share

Authors

PXPengwei XuXWXin WangTWTuo Wang

Discussion

Loading...

Member takes

Overview

This review highlights the role of C-F bond interactions in influencing the reactivity and selectivity of organic reactions, suggesting future applications in synthesis.

Key Points

  • C-F⋯H-X interactions significantly influence both reactivity and selectivity in organic reactions, expanding our understanding of non-classical hydrogen bonds.
  • Evidence suggests that C-F bonds can act as hydrogen bond acceptors, affecting the outcome of organic reactions and enhancing the design of new reagents.
  • The review summarizes recent advances in understanding the role of hydrogen-bonding interactions, pointing to their potential in rational compound design.
  • Exploring C-F bond interactions presents new opportunities for developing precise synthesis strategies in organic chemistry.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d6e14f8b2b6861e4c3fbdahttps://doi.org/10.1039/d4cs01269k
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Understanding organofluorine chemistry. An introduction to the C–F bond2007 · 4,053 citations
  2. 2The Effect of the Substituent's Nature on the Crystallographic and Quantum‐Chemical Profile of the Fluorine–Fluorine Interaction2025
  3. 3Negative σ-Holes on Fluorine in Molecules Revisited: Halogen Bonding or Counterintuitive, Anti-Electrostatic Interactions?2026 · 1 citations
  4. 4On the Nature of Improper Hydrogen Bonding in RCH <sub>2</sub> F and RCHF <sub>2</sub> Motifs2025
  5. 5On the Nature of Improper Hydrogen Bonding in RCH <sub>2</sub> F and RCHF <sub>2</sub> Motifs2025