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November 11, 2025Chinese MedicineOpen Access

Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis

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Authors

FZFangsi ZhuYDYijie DingLCLuyun Chen

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Overview

Study finds Sini-San regulates bile acids and gut microbiota in liver fibrosis, suggesting a therapeutic approach.

Key Points

  • This research explores how Sini-San affects bile acid metabolism in liver fibrosis models.
  • Characterization of chemical constituents using high-performance liquid chromatography (HPLC).
  • Liver fibrosis models induced by CCl4 and high-fat high-sugar diet.
  • Oral administration of Sini-San; measurement of ALT, AST, hydroxyproline; liver histopathology via staining methods.
  • Analysis of bile acid profiles using LC-MS/MS and gut microbiota composition through 16S rRNA sequencing.
  • Sini-San treatment improved liver injury and fibrosis in CCl4 and HFHS-induced mice.
  • Bile acid levels and composition were significantly altered in liver fibrosis models.
  • SNS regulated the expression of bile acids-synthesizing enzymes and transporters, restoring homeostasis.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/69252e9ec0ce034ddc356576https://doi.org/10.1186/s13020-025-01252-5
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Also Consider

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  1. 1Si-Ni-San improves the deposition of lipid droplets in MAFLD through modulating the FXR-GPAT4 axis2026
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  4. 4Sanzi Sijun Formula Alleviates Lipotoxic Liver Injury in Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/SIRT1 Signaling Pathway2026
  5. 5Sini San ameliorates lipid metabolism in hyperprolactinemia rat with liver-depression2024 · 8 citations