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September 10, 2025

Si-Ni-San improves the deposition of lipid droplets in MAFLD through modulating the FXR-GPAT4 axis

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Authors

HFHaibo FanYHYunfei HouYLYue Li

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Overview

Observational analysis improves hepatic lipid droplet accumulation in MAFLD models, indicating FXR's role in fat metabolism.

Key Points

  • Si-Ni-San significantly reduces lipid droplet deposition in MAFLD models, enhancing liver function and health.
  • The study highlights a key finding: FXR transcriptionally regulates GPAT4, which is critical in lipid droplet management.
  • Mice and HepG2 cell models were utilized to explore the interaction between FXR and GPAT4 via advanced molecular techniques.
  • These results suggest that targeting the FXR-GPAT4 axis may open new therapeutic avenues for metabolic-associated fatty liver disease.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68c1956b9b7b07f3a0619ab8https://doi.org/10.21203/rs.3.rs-7457859/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Si-Ni-San improves the deposition of lipid droplets in MAFLD through modulating the FXR-GPAT4 axis2026
  2. 2Regulatory effects of Sini-San on bile acid homeostasis in the enterohepatic circulation of mice with liver fibrosis2025
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