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November 28, 2025Journal of Pharmacy and Pharmacology

Revealing action mechanisms of Xiaoyaosan decoction for the treatment of nonalcoholic fatty liver in mice employing tandem mass tag quantitative proteomics

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Authors

HJHong Xiang JiangYLYa Ge LiCSChao Sun

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Overview

Observational analysis revealed lipid accumulation reduction in C57BL/6 mice with NAFL, indicating PPARα activation may explain therapeutic effects of Xiaoyaosan decoction.

Key Points

  • Xiaoyaosan decoction improved liver steatosis in NAFL model mice, showing potential therapeutic effects.
  • Treatment resulted in improved gene expression of Fads2 and reduced lipid accumulation in liver tissues.
  • Analysis used tandem mass tag proteomics and bioinformatics to explore metabolic pathways involved.
  • Findings suggest activation of PPARα signaling could be key in managing nonalcoholic fatty liver disease.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a200https://doi.org/10.1093/jpp/rgaf109
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