What question did this study set out to answer?

This research aims to identify transferrin receptor as a potential prognostic biomarker and therapeutic target in esophageal squamous cell cancer.

November 11, 2025Cancer ScienceOpen Access

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

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Authors

NINaoki Ikenaga TTTsuyoshi Takahashi KTKoji Tanaka

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Implication

Research reveals high transferrin receptor expression correlates with poor prognosis in esophageal squamous cell cancer, suggesting iron metabolism targeting may improve treatment outcomes.

Key Points

This research aims to identify transferrin receptor as a potential prognostic biomarker and therapeutic target in esophageal squamous cell cancer.
Utilized proteomic technology to identify transferrin receptor in ESCC.
Evaluated clinicopathological characteristics using immunohistochemistry on ESCC specimens.
Knockdown experiments were performed in ESCC cell lines to assess effects on iron levels and proliferation.
Xenograft mouse model utilized to evaluate effects of deferoxamine treatment on tumor size and serum iron levels.
High transferrin receptor expression associated with poor prognosis in ESCC.
Knockdown of transferrin receptor led to decreased intracellular iron and suppressed cell proliferation.
Deferoxamine treatment reduced tumor size and serum iron levels in the xenograft model.
Iron deficiency induced increased transferrin receptor expression via upregulation of iron regulatory protein 2.

Cite This Study

Ikenaga et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc35677d https://doi.org/10.1111/cas.70195

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Implication

Research reveals high transferrin receptor expression correlates with poor prognosis in esophageal squamous cell cancer, suggesting iron metabolism targeting may improve treatment outcomes.

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Overexpression of Transferrin Receptor in Esophageal Squamous Cell Cancer Suggests Poor Prognosis and Potential Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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