What question did this study set out to answer?

Investigate the relationship between transferrin receptor (TFR1) overexpression and treatment outcomes in solid tumors.

May 1, 2026CancersOpen Access

Transferrin Receptor Overexpression in Solid Tumors Is Associated with Inflamed Microenvironments and Upregulated Immune Checkpoints, with Implications for Immunotherapy Sensitivity

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Randomized trial assesses cancer outcomes related to transferrin receptor overexpression, indicating implications for immunotherapy sensitivity.

Investigate the relationship between transferrin receptor (TFR1) overexpression and treatment outcomes in solid tumors.
Utilized a pan-cancer database of 93,248 patients with whole-exome and whole-transcriptome sequencing.
Assessed TFRC-associated multiomic patterns and overall survival across various tumor types.
Performed cell line models to evaluate susceptibility to cytotoxic T cells with elevated iron metabolism.
High TFRC expression correlates with worse overall survival in multiple solid tumor types.
Increased tumor mutational burden and infiltration of immune effector cells with elevated immune checkpoint markers were observed.
Cell lines showed greater susceptibility to cytotoxic T cells despite PD-L1 upregulation.

Trabolsi et al. (2026) studied this question.

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Randomized trial assesses cancer outcomes related to transferrin receptor overexpression, indicating implications for immunotherapy sensitivity.