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November 11, 2025Frontiers in GeneticsOpen Access

Computational-experimental strategy identifies Co-upregulated biomarkers linking coronary heart disease and type 2 diabetes pathogenesis

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Authors

WLWei LiYCYu CaoCYChen Yu

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Overview

Integrated bioinformatics reveals shared biomarkers and histopathological changes in coronary heart disease and type 2 diabetes, suggesting common pathways.

Key Points

  • This research aims to identify shared biomarkers linking coronary heart disease and type 2 diabetes along with their core pathways.
  • Used bioinformatics to analyze CHD/T2D transcriptomes
  • Identified shared differentially expressed genes and co-expression modules
  • Validated findings in C57BL/6 and ApoE −/− mouse models using various assays
  • Discovered 328 shared differentially expressed genes
  • Validated CPD, GGCT, SUZ12, and ZMYM2 as effective diagnostic biomarkers
  • Observed histopathological changes in aortic tissues, including atherosclerotic plaques in CHD and thickening in T2D

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69252ea8c0ce034ddc356955https://doi.org/10.3389/fgene.2025.1673303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 11797-LB: Detection of Potential Therapeutic Target Associated with Coronary Artery Disease in Type 2 Diabetes Patients—System Biology Approach2024
  2. 2A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease2025
  3. 3Identification of diabetes related phenotype and diagnostic biomarkers in coronary artery disease2025
  4. 4CD8+ T and NK cells characterized by upregulation of NPEPPS and ABHD17A are associated with the co-occurrence of type 2 diabetes and coronary artery disease2024 · 6 citations
  5. 5Transcriptional profiles associated with coronary artery disease in type 2 diabetes mellitus2024 · 5 citations