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November 10, 2025Epiliepsy currents/Epilepsy currentsOpen Access

Stay or Go: Decision-Making Surrounding Antiseizure Medication Discontinuation

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Authors

STSamuel W Terman

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Overview

Cross-sectional study reveals psychosocial factors and anxiety scores influence antiseizure medication decisions in epilepsy care, suggesting improved shared decision-making is needed.

Key Points

  • To investigate clinical and psychosocial factors affecting antiseizure medication non-discontinuation in seizure-free epilepsy patients.
  • Cross-sectional study design.
  • Neurologists documented recommendations on antiseizure medication discontinuation.
  • Participants included patients aged ≥18 years who had been seizure-free for at least 2 years.
  • Patient decisions were based on neurologists' recommendations and psychosocial questionnaires.
  • Neurologists recommended antiseizure medication discontinuation in 56.1% of cases.
  • Only 26.4% of patients agreed to discontinue their medication.
  • Longer seizure-free duration and higher anxiety scores were significant predictors of non-discontinuation.
  • Shared decision-making remains complex with differing perspectives between neurologists and patients.

Cite This Study

Samuel W Terman (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356c90https://doi.org/10.1177/15357597251390600
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A mixed-methods study of patient perspectives on antiseizure medication discontinuation attempts after a period of seizure-freedom2026
  2. 2Exit Strategy: Balancing the Risks and Rewards of Antiseizure Medication Withdrawal2024 · 9 citations
  3. 3Risk of Recurrence After Anti-Seizure Medication Discontinuation2024 · 1 citations
  4. 4Beliefs About Anti-seizure Medications in Seizure-free Adults with Epilepsy (P8-1.014)2024
  5. 5Trends in Antiseizure Medication Initiation, Switch, or Termination in Patients With Newly Diagnosed Epilepsy2024 · 11 citations