This review demonstrates the role of inflammation and proteolytic activity in abdominal aortic aneurysm progression, suggesting targeted therapies may improve outcomes.
Key Points
This review explores mechanisms of abdominal aortic aneurysm progression and treatment challenges.
Review of preclinical and clinical data
Analysis of risk factors and biological mechanisms
Evaluation of current and novel therapeutic strategies
Abdominal aortic aneurysm progression is linked to inflammation and endothelial dysfunction
Targeting proteases may mitigate aneurysm growth
Current therapies show limited efficacy, highlighting the need for personalized approaches