Key result
Current evidence suggests that abdominal aortic aneurysm progression is driven by the interaction of the hemodynamic microenvironment with local and systemic immune responses.
Why the study?
Controversy persists regarding abdominal aortic aneurysm treatment methods, and the mechanisms of progression remain poorly defined, complicating the targeting of new therapies.
This review summarizes current evidence on the mechanisms of abdominal aortic aneurysm progression, emphasizing the complex interplay between hemodynamics and immune responses.
Highlights AAA immune-hemodynamic mechanisms; leaves open targeted therapy trials before clinical adoption.
Abdominal aortic aneurysm (AAA) is a common disease associated with significant cardiovascular morbidity and mortality. Up to now, there is still controversy on the choice of treatment method of AAA. Even so, the mechanisms of AAA progression are poorly defined, making targeting new therapies problematic. Current evidence favors an interaction of the hemodynamic microenvironment with local and systemic immune responses. In this review, we aim to provide an update of mechanisms in AAA progression, involving hemodynamics, perivascular adipose tissue, adventitial fibroblasts, vasa vasorum remodeling, intraluminal thrombus, and distribution of macrophage subtypes.
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A 2021 study conducted a review in Abdominal aortic aneurysm. Current evidence suggests that abdominal aortic aneurysm progression is driven by the interaction of the hemodynamic microenvironment with local and systemic immune responses.
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