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November 10, 2025Advanced Healthcare Materials

Oxygen‐Vacancy‐Engineered Self‐Regenerative Nanozymes in Dual‐Signal‐Responsive Dynamic Hydrogels: A Closed‐Loop Therapeutic Strategy for Diabetic Wound Microenvironment Remodeling

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Authors

XFxianchun fuJWJing WangHZHan Zhang

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Overview

Closed-loop therapeutic strategy improves wound healing and reduces infection in diabetic patients, highlighting the roles of hydrogel and nanozymes.

Key Points

  • Closed-loop hydrogel dressing enhances wound healing dynamics in diabetic ulcers, reducing infection rates.
  • The inclusion of curcumin and molybdenum oxide nanozymes supports a 99.9% reduction in biofilm growth.
  • Observational analysis on the self-regenerative processes of Cu-doped nanozymes in hydrogen peroxide decomposition shows significant catalytic action.
  • This method calls for improved approaches in treating diabetic wounds to address persistent nonhealing challenges.

Cite This Study

fu et al. (2025) studied this question.

synapsesocial.com/papers/69253a1ec0ce034ddc356f59https://doi.org/10.1002/adhm.202504199
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing2024 · 130 citations
  2. 2Self‐Evolving Hydrogel Dressing Temporally Accelerates Infected Diabetic Wound Healing2026 · 5 citations
  3. 3A self-oxygenating polyphenol-nanozyme hydrogel remodels the inflammatory microenvironment for diabetic wound healing2026
  4. 4Specific Nanozyme‐Based Cascade Catalysis Hydrogel With Oxygen‐Self‐Supplying and ROS‐Scavenging Capacity for Efficient Diabetic Wound Healing2026
  5. 5Reprogramming the Diabetic Wound Microenvironment by Enzyme Cascade-Driven, ROS-Responsive Microspheres2026