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November 11, 2025ACS Applied Materials & Interfaces

A Self-Oxygenating Nanozyme Cascade System for Drug-Resistant Bacterial Infected Diabetic Wound Healing

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Authors

NWNingning WangWMWenying MuIKIrina A. Kolesnik

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Overview

Observational analysis reveals enhanced wound healing in diabetic models using Nanozyme systems, suggesting improved outcomes against bacterial infections.

Key Points

  • CFO@PEG NPs achieved 99.9% eradication of methicillin-resistant bacteria, enhancing wound healing.
  • In vitro tests showed significant biofilm clearance and reactive oxygen species generation.
  • Trial investigated the roles of different enzymes in healing MRSA-infected diabetic wounds.
  • Highlights therapeutic potential for addressing multidimensional challenges in wound care under persistent infection.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69252e90c0ce034ddc3560f2https://doi.org/10.1021/acsami.5c20613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cascade catalytic nanozyme platform for combined antibacterial, anti-inflammatory, and pro-healing therapy of infected diabetic wounds2026 · 1 citations
  2. 2Self-Reinforcing Nanozyme-Integrated Microneedles Orchestrate Cascaded Regulation of ROS Homeostasis for Infected Wound Healing2026
  3. 3Manganese Carbonyl-Based Peroxidase-like Nanoenzyme Cascading with Glucose Oxidase, Combined with Porphyrin-COFs-Based Phototherapy and CO-Mediated Immunomodulation for Diabetic Wound Repair2026
  4. 4Dynamic Antibacterial‐to‐Regenerative Switching via NIR/Visible Light Activation: Copper Single‐Atom Nanozyme with CO‐Mediated Scarless Healing for Chronic Diabetic Wounds2025 · 8 citations
  5. 5Oxygen‐Vacancy‐Engineered Self‐Regenerative Nanozymes in Dual‐Signal‐Responsive Dynamic Hydrogels: A Closed‐Loop Therapeutic Strategy for Diabetic Wound Microenvironment Remodeling2025