What does this research mean for the field?

A triple-synergistic nanoenzyme platform (Por-COF@GOx/MnCO) combining phototherapy, peroxidase-like activity, and CO-mediated immunomodulation achieves over 99.99% antibacterial efficiency and significantly accelerates diabetic wound healing. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate a triple-synergistic nanoenzyme platform integrating catalytic activity, phototherapy, and carbon monoxide-mediated immunomodulation for accelerated diabetic wound healing.

September 5, 2026ACS Applied Materials & Interfaces

Manganese Carbonyl-Based Peroxidase-like Nanoenzyme Cascading with Glucose Oxidase, Combined with Porphyrin-COFs-Based Phototherapy and CO-Mediated Immunomodulation for Diabetic Wound Repair

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Authors

NXNingning Xu YZYi Zhang YLYu Liu

Discussion

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Overview

Experimental study demonstrates enhanced bacterial clearance and tissue regeneration in diabetic wound models, suggesting a potent multifunctional nanoplatform for chronic wound repair.

Key Points

To develop and evaluate a triple-synergistic nanoenzyme platform integrating catalytic activity, phototherapy, and carbon monoxide-mediated immunomodulation for accelerated diabetic wound healing.
Synthesized a porphyrin covalent organic framework coloaded with glucose oxidase and manganese carbonyl (Por-COF@GOx/MnCO).
Evaluated light-triggered photothermal and photodynamic reactions, glucose-depleting cascade catalysis producing toxic hydroxyl radicals, and carbon monoxide release.
Assessed antibacterial efficacy against multiple bacterial strains, along with in vitro and in vivo evaluations of macrophage polarization, angiogenesis, and wound closure.
Achieved greater than 99.99% antibacterial efficiency against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA).
Promoted M1-to-M2 macrophage polarization to relieve inflammation and suppressed heat-shock proteins via controlled carbon monoxide release to enhance photothermal therapy.
Accelerated diabetic wound healing by promoting angiogenesis, scavenging excess reactive oxygen species, and restoring tissue repair mechanisms.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3f16b95aff0620eb3e5 https://doi.org/10.1021/acsami.6c13461

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September 5, 2026ACS Applied Materials & Interfaces

Manganese Carbonyl-Based Peroxidase-like Nanoenzyme Cascading with Glucose Oxidase, Combined with Porphyrin-COFs-Based Phototherapy and CO-Mediated Immunomodulation for Diabetic Wound Repair

View Full Paper

Ask AI

Bookmark

Authors

NXNingning Xu YZYi Zhang YLYu Liu

Discussion

Member takes

Overview

Experimental study demonstrates enhanced bacterial clearance and tissue regeneration in diabetic wound models, suggesting a potent multifunctional nanoplatform for chronic wound repair.

Key Points

To develop and evaluate a triple-synergistic nanoenzyme platform integrating catalytic activity, phototherapy, and carbon monoxide-mediated immunomodulation for accelerated diabetic wound healing.
Synthesized a porphyrin covalent organic framework coloaded with glucose oxidase and manganese carbonyl (Por-COF@GOx/MnCO).
Evaluated light-triggered photothermal and photodynamic reactions, glucose-depleting cascade catalysis producing toxic hydroxyl radicals, and carbon monoxide release.
Assessed antibacterial efficacy against multiple bacterial strains, along with in vitro and in vivo evaluations of macrophage polarization, angiogenesis, and wound closure.
Achieved greater than 99.99% antibacterial efficiency against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA).
Promoted M1-to-M2 macrophage polarization to relieve inflammation and suppressed heat-shock proteins via controlled carbon monoxide release to enhance photothermal therapy.
Accelerated diabetic wound healing by promoting angiogenesis, scavenging excess reactive oxygen species, and restoring tissue repair mechanisms.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3f16b95aff0620eb3e5 https://doi.org/10.1021/acsami.6c13461

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