Continuous-Flow Electrochemistry Enables 1,2-Arylheteroarylation of Alkenes

Despite its potential, the radical-mediated 1,2-arylheteroarylation of alkenes for constructing valuable 1,2-arylheteroaryl ethane motifs remains underdeveloped. We herein report an alternative continuous-flow electrochemical approach using alkenes, aryl bromides, and cyanopyridines as coupling partners. This method eliminates the need for sacrificial anodes, catalysts, or chemical oxidants, requires minimal electrolyte, and achieves high regioselectivity. Its utility is underscored by successful applications in the late-stage functionalization of bioactive molecules.