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November 10, 2025AddictionOpen Access

Electrophysiological sexual dimorphism as an early risk marker of alcohol use in adolescence: A longitudinal neuroimaging study

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Authors

ALAlberto del Cerro LeónMUMarcos UcetaDSDanylyna Shpakivska-Bilan

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Overview

Longitudinal study shows correlation between neuroimaging markers and alcohol use in adolescents, suggesting sex differences in risk behaviors.

Key Points

  • To identify brain activity profiles associated with alcohol consumption and explore their relationship to excitation–inhibition balance and sex differences.
  • Longitudinal study with neuroimaging assessment including MEG and MRI.
  • Participants were 56 adolescents aged 13-17 from Madrid prior to alcohol use initiation.
  • Follow-up assessment conducted two years later using the same measures.
  • Beta-band power spectra positively correlated with alcohol use at baseline (rho = 0.33, P < 0.05) and follow-up (rho = 0.35, P < 0.05).
  • Negative correlation observed between excitation–inhibition ratio and alcohol use at both assessments (baseline: rho = −0.56, P < 0.001; follow-up: rho = −0.37, P < 0.01).
  • Biological sex moderated these relationships, with females showing a stronger predictive correlation (P < 0.001, rho = 0.64).

Cite This Study

León et al. (2025) studied this question.

synapsesocial.com/papers/69253a1ec0ce034ddc356fafhttps://doi.org/10.1111/add.70246
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