Case report identifies diagnostic challenges in renal masses, highlighting similarities to urothelial carcinoma.
Background We present a rare case of Primary Renal Lymphoma (PRL) diagnosed on histopathology following robotic nephroureterectomy. This case explores the diagnostic and management challenges urologists face, when treating renal masses. Case presentation An 82-year-old male presented with recurrent macroscopic haematuria and a computed tomography intravenous pyelogram (CT IVP) reported renal papillary necrosis and an associated mass effect at the right renal pelvis. Urine cytology was inconclusive, whilst inpatient pyeloscopy revealed a renal pelvis tumour. This was biopsied and reported as suspicious for urothelial carcinoma. Multidisciplinary team discussion (MDT) recommended curative surgery. Following right nephroureterectomy, postoperative histology revealed a diffuse large B-Cell lymphoma (DLBCL) extending through the renal capsule into perirenal fat, renal vein and renal pelvis. Conclusion We highlight the clinical similarities between upper tract urothelial carcinoma (UTUC) and PRL, encouraging urologists to consider biopsies of indeterminate lesions, particularly amongst the frail population.
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McMaster et al. (2025) studied this question.
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