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November 10, 2025DiagnosticsOpen Access

Prognostic Value of Primary Total Glossectomy in Tongue Cancer: A Systematic Review and Meta-Analysis of Survival Outcomes

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Authors

MSM. P. SreeramPDPrajwal DangeKRKarthik N Rao

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Overview

Systematic review shows total glossectomy impacts survival and recovery in tongue cancer, highlighting the need for multidisciplinary care.

Key Points

  • This research aims to evaluate survival rates and functional recovery after total glossectomy in tongue cancer patients.
  • Proportional meta-analysis of studies on primary total glossectomy outcomes
  • Exclusion of studies combining TG with laryngectomy or salvage settings
  • Quality assessment with the Newcastle–Ottawa Scale
  • Pooled survival estimates calculated using random-effects model
  • Heterogeneity quantified and sensitivity analyses performed.
  • Pooled 1-year overall survival was 81%; 3-year at 55%; 5-year at 47%
  • Post-2000 studies showed improved 5-year overall survival at 63%
  • Adverse prognostic factors included advanced T stage, nodal disease, and positive margins
  • Functional recovery varied, with 15-30% gastrostomy-dependent and 20-25% aspirating
  • Reconstruction and structured rehabilitation improved functional outcomes.

Cite This Study

Sreeram et al. (2025) studied this question.

synapsesocial.com/papers/69253a24c0ce034ddc3572d1https://doi.org/10.3390/diagnostics15222847
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tumor and Flap Reconstruction Volumes and Functional Outcomes after Glossectomy2026
  2. 2Subtotal and total glossectomies with or without total laryngectomy – Does laryngeal preservation impact oncological and functional outcomes?2026
  3. 3Functional outcomes and quality of life after partial glossectomy for tongue carcinoma: A prospective observational study.2026
  4. 4Oncologic Outcomes of Salvage Surgery in Recurrent Oral Tongue Squamous Cell Carcinoma2024
  5. 5Functional outcome of carcinoma tongue after primary surgical treatment2024 · 1 citations