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March 21, 2026JAMA Otolaryngology–Head & Neck Surgery

Tumor and Flap Reconstruction Volumes and Functional Outcomes after Glossectomy

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Authors

SWShannon S. WuPalo Alto UniversityAJAnushka JetlyPalo Alto UniversityHSHeather M. StarmerStanford Medicine

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Implication

Retrospective cohort study evaluates impacts of surgical resection volume on swallowing and speech in oral cancer patients, suggesting enhanced preoperative guidance.

Key Points

  • To examine how tumor volume and the extent of tongue resection affect functional outcomes like swallowing and speech in patients with oral cancer.
  • Retrospective cohort study of patients with squamous cell carcinoma undergoing glossectomy from 2014 to 2025.
  • Assessment of demographic, tumor, and postoperative outcomes using validated tools.
  • Comparison of functional outcomes based on partial vs total glossectomy and volumetric analyses of tumors and resection.
  • Application of multivariable and nonlinear regression modeling to identify associations between volumes and outcomes.
  • The TG group showed significantly worse functional outcomes across various metrics compared to PG group.
  • Identified factors like older age and smoking linked to poor oral intake and speech intelligibility.
  • Higher tumor and resection volume fractions correlated with worse functional outcomes like gastrostomy dependency and speech understandability.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/69be35836e48c4981c673d04https://doi.org/10.1001/jamaoto.2026.0099
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of Speech and Functional Outcomes in Tongue Reconstruction after Hemiglossectomy2020 · 30 citations
  2. 2Functional outcome after total and subtotal glossectomy with free flap reconstruction2008 · 67 citations
  3. 3Functional Outcomes after Subtotal/Total Glossectomy with Microsurgical Reconstruction: A Multicenter Prospective Observational Study in Japan2025 · 4 citations
  4. 4Comparative study of functional outcomes following surgical treatment of early tongue cancer2021 · 21 citations