Analysis uncovers biomarkers in granulosa cells, suggesting immune-metabolic links in polycystic ovary syndrome.
Our findings highlight granulosa cells as central mediators of immune-metabolic disruption in PCOS and identify CLDN11, HLA-DMA, TAB3, COLQ, and LYN as potential biomarkers and regulatory targets. The integrative approach combining bioinformatics and in vitro validation provides new insights into the pathophysiology of PCOS and supports future development of cell-specific diagnostic and therapeutic strategies.
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Luo et al. (2025) studied this question.
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