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November 10, 2025Wiley Interdisciplinary Reviews Forensic Science

Evolution of Analytical Methods for the Determination of Ethanol in Blood and Breath for Clinical and Forensic Purposes

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Authors

AJAlan W. Jones

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Overview

Historical review highlights advances in methods for measuring blood alcohol concentration, indicating improved techniques for clinical and forensic toxicology.

Key Points

  • To provide a retrospective account of advancements in analytical methods for ethanol detection in blood and breath.
  • Historical analysis of laboratory procedures for ethanol determination
  • Overview of enzymatic oxidation and Breathalyzer instrument development
  • Discussion of gas-liquid chromatography and mass spectrometry applications in forensic analysis
  • Enhanced sensitivity and specificity achieved with the ADH method
  • Introduction of automated laboratory procedures
  • Modern breath-alcohol analysis employs infrared spectrometry and electrochemical methods

Cite This Study

Alan W. Jones (2025) studied this question.

synapsesocial.com/papers/69253a31c0ce034ddc3577f6https://doi.org/10.1002/wfs2.70018
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