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September 10, 2025Biochemia MedicaOpen Access

The enzymatic analysis of alcohol (ethanol) in serum and plasma with the alcohol dehydrogenase reagent: focus on intra-analytical and post-analytical aspects

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Authors

CICristiano IalongoAJAlan Wayne Jones

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Overview

This review highlights factors affecting ethanol measurement accuracy in clinical and forensic settings.

Key Points

  • Ethanol measurement using alcohol dehydrogenase shows critical reliability and defensibility in emergency settings.
  • The yeast ADH method is highly selective for ethanol, meeting regulatory standards for measurement error and uncertainty.
  • Intra-analytical and post-analytical factors can significantly alter results, complicating interpretation in legal contexts.
  • ADH methods are prone to interferences from compounds like lactate dehydrogenase, which may lead to false results.

Cite This Study

Ialongo et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb6a54b1d3bfb60ed519https://doi.org/10.11613/bm.2025.030501
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolution of Analytical Methods for the Determination of Ethanol in Blood and Breath for Clinical and Forensic Purposes2025
  2. 2Simultaneous determination of four ethanol biomarkers in blood: avalidated method for use in forensic toxicology in 257 postmortem samples2024
  3. 3Estimation of the kinetic parameters (Km & Vmax) and the optimization of yeast alcohol dehydrogenase (ADH) assay.2024 · 1 citations
  4. 4Enzymatic Ethanol Assay v22021
  5. 5Dual-Column HS-GC-FID/FID Method for In-Depth Analysis of Low-Molecular-Weight Volatile Alcohols in Postmortem Biological Material2026