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November 8, 2025PharmaceuticalsOpen Access

Modulation of Nrf2 and Mitochondrial Function: Pharmacological Implications

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Authors

LSLuciano SasoIAIlker AtesRTRamazan Tunc

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Overview

This review shows Nrf2 modulation improves mitochondrial function and oxidative stress in cellular systems, suggesting pharmacological implications for disease treatment.

Key Points

  • This review explores the role of Nrf2 in regulating mitochondrial function and oxidative stress.
  • Review of recent studies on Nrf2 and mitochondrial function
  • Analysis of Nrf2's influence on oxidative stress
  • Discussion of pharmacological implications for Nrf2 activation
  • Nrf2 modulates mitochondrial function by supporting mitophagy
  • Elevated Nrf2 levels protect cells from mitochondrial toxins
  • Pharmacological activation of Nrf2 counters mitochondrial dysfunction

Cite This Study

Saso et al. (2025) studied this question.

synapsesocial.com/papers/69253a35c0ce034ddc357babhttps://doi.org/10.3390/ph18111698
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