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June 21, 2026Obesity Research & Clinical PracticeOpen Access

Nrf2 in obesity: Mechanisms, models, and bioactive modulators

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Authors

ISIrina N. ShalovaAMAlessandro MedoroSDSergio Davinelli

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Overview

Review highlights Nrf2's dual role in obesity-related pathways, emphasizing therapeutic potential and complexities.

Key Points

  • This review aims to explore the mechanistic roles of Nrf2 in obesity, highlighting its relationships with inflammation and metabolism.
  • Integrated review of genetic and pharmacological models related to Nrf2 and obesity.
  • Discussion of bioactive compounds that modulate Nrf2 and their therapeutic potential.
  • Analysis of existing clinical evidence related to Nrf2 modulation and obesity.
  • Nrf2 is identified as a key regulator linking inflammation and obesity-related pathways.
  • Some bioactive compounds have shown promise in clinical trials for activating Nrf2 and exerting anti-obesity effects.
  • Current clinical evidence on Nrf2's role in obesity is limited compared to its implications in metabolic syndrome and related diseases.

Cite This Study

Shalova et al. (2026) studied this question.

synapsesocial.com/papers/6a37815a24f042ddf4c5b3d3https://doi.org/10.1016/j.orcp.2026.06.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of NRF2 in Obesity-Associated Cardiovascular Risk Factors2022 · 62 citations
  2. 2Nrf2 Activation in Inflammatory Diseases: A Review of Natural and Synthetic Modulators2026 · 11 citations
  3. 3Nrf2 signaling pathway and its molecular regulatory mechanism2026
  4. 4Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity2010 · 300 citations
  5. 5Modulation of Nrf2 and Mitochondrial Function: Pharmacological Implications2025