What type of study is this?

This is a Systematic Review study.

What question did this study set out to answer?

To evaluate the physiological and preventive functions of vitamin D and its involvement in multiorgan diseases.

November 7, 2025BiomedicinesOpen Access

Vitamin D as a Systemic Regulatory Axis: From Homeostasis to Multiorgan Disease

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Authors

MRMaria Rodriguez Rivero MMMiguel Angel Medina MRMaria Rodriguez Rivero

Discussion

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Implication

Review demonstrates vitamin D's multifaceted roles in immunity and disease prevention in various populations, suggesting need for tailored supplementation strategies.

Key Points

To evaluate the physiological and preventive functions of vitamin D and its involvement in multiorgan diseases.
Systematic literature review conducted per PRISMA 2020 guidelines
Database search in PubMed, Scopus, and Web of Science
Rigorous inclusion and exclusion criteria applied in three phases: blind search, title/abstract selection, and full-text evaluation
Vitamin D acts as a transcriptional modulator beyond the skeletal system
Associations identified between low 25(OH)D levels and higher prevalence of autoimmune, neurodegenerative, and metabolic diseases
Current evidence of causality is limited, with mixed results from clinical trials on preventive efficacy

Cite This Study

Rivero et al. (2025) studied this question.

synapsesocial.com/papers/69253a39c0ce034ddc357cf9 https://doi.org/10.3390/biomedicines13112733

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Implication

Review demonstrates vitamin D's multifaceted roles in immunity and disease prevention in various populations, suggesting need for tailored supplementation strategies.

Vitamin D as a Systemic Regulatory Axis: From Homeostasis to Multiorgan Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Vitamin D as a Systemic Regulatory Axis: From Homeostasis to Multiorgan Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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