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November 7, 2025Modern Rheumatology Case Reports

Myalgia as Initial Presentation of Microscopic Polyangiitis: Diagnostic Utility of Kidney Biopsy

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Authors

MWMiyu WakatsukiYOYuki ObaJKJunko Kanda-Kikuchi

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Overview

Case report reveals myalgia as a clinical feature of microscopic polyangiitis, indicating kidney biopsy aids diagnosis.

Key Points

  • This case explores the diagnostic challenge of myalgia as an initial symptom of microscopic polyangiitis.
  • Case report of a 60-year-old male with myalgia and gait disturbance
  • MRI showed high signal intensity in lower limb muscles indicative of myositis
  • Kidney biopsy revealed fibrinoid necrosis despite minimal renal symptoms.
  • Serology positive for MPO-ANCA, with negative myositis-specific autoantibodies
  • Muscle biopsy results were inconclusive while normal creatine kinase levels were found
  • Kidney biopsy provided a definitive diagnosis of microscopic polyangiitis
  • MPA should be considered in myalgia cases, particularly with positive MPO-ANCA.

Cite This Study

Wakatsuki et al. (2025) studied this question.

synapsesocial.com/papers/69253a39c0ce034ddc357d14https://doi.org/10.1093/mrcr/rxaf062
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary nodules in a case of microscopic polyangiitis: a case report and review of the literature2026
  2. 2Don’t Miss Vasculitic Myopathy Without Elevated Creatine Phosphokinase2026
  3. 3Microscopic polyangiitis with isolated cardiopulmonary involvement: A case report2025
  4. 4Look Here, Not There! Vasculitic Myopathy and a Tale of Masquerades2026
  5. 5Membranous nephropathy in patients with anti-myeloperoxidase antibody associated systemic vasculitis: a report of two cases2025