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November 6, 2025Current ZoologyOpen Access

Sex-dependent Biobehavioural Responses to Transgenerational Maternal Stress: Evidence of Stress Resilience and Vulnerability in the F3 Generation

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Authors

JFJamshid FarajiNSNicola SchatzSKStephanie King

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Overview

Findings show maternal prenatal stress impacts anxiety and HPA axis responses in male and female rats indicating sex-based vulnerability.

Key Points

  • This research investigates how maternal prenatal stress affects stress responses in the F3 generation of rats, focusing on sex differences.
  • Examined neurohormonal responses and behaviour in F3 male and female rats born to stressed and non-stressed lineages.
  • Induced maternal stress in pregnant females of the ancestral F0 generation.
  • Assessed HPA axis activity, corticosterone levels, and behaviour in open field and elevated plus maze tasks.
  • F3 males showed HPA axis hyperactivity compared to non-stressed males.
  • F3 females had significantly higher corticosterone levels than males despite no change in HPA axis activity.
  • Maternal stress elevated cytokines IL-1β and IL-10 exclusively in F3 females.
  • F3 females exhibited more pronounced anxiety- and depressive-like symptoms than males.

Cite This Study

Faraji et al. (2025) studied this question.

synapsesocial.com/papers/69253a39c0ce034ddc357df6https://doi.org/10.1093/eep/dvaf031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transgenerational effect of prenatal stress on behavior and lipid peroxidation in brain structures of female rats during the estral cycle2024
  2. 2Maternal stress effects across generations in a precocial bird2024 · 3 citations
  3. 3Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice2025 · 3 citations
  4. 4Transgenerational Transmission of Maternal Stress in Males: MSUS-Induced NSCs Depletion and Adult Hippocampal Neurogenesis Impairment2026
  5. 5Multilevel sex-influenced neurobiological signatures of early life adversity2026