What question did this study set out to answer?

This research aims to evaluate the utility of cfDNA and cfRNA in the diagnosis and monitoring of CNS tumors.

November 1, 2025Neuro-OncologyOpen Access

INNV-08. Using cell free DNA (cfDNA) and RNA (cfRNA) in the diagnosis and monitoring of primary and metastatic CNS tumors

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Analysis reveals neoplastic process in 79% of metastatic cases using cfDNA and next generation sequencing, suggesting impactful clinical decisions.

This research aims to evaluate the utility of cfDNA and cfRNA in the diagnosis and monitoring of CNS tumors.
Tested 970 CSF samples for genomic abnormalities using cfDNA and cfRNA extraction.
Utilized next generation sequencing with a targeted DNA panel of 302 genes and an RNA panel of 1600 genes.
Applied hybrid capture technique based on KAPA HyperPrep kit.
79% of metastatic tumor cases showed abnormalities associated with neoplastic processes.
Identified clonal hematopoiesis in a minority of cases and specific gene mutations in others.
Detected actionable mutations like EGFR and ESR1 in a significant percentage of cancer cases.

Albitar et al. (2025) studied this question.

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Analysis reveals neoplastic process in 79% of metastatic cases using cfDNA and next generation sequencing, suggesting impactful clinical decisions.