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November 1, 2025Neuro-OncologyOpen Access

IMG-01. Higher Cerebral Metabolic Rate of Oxygen derived from Dynamic Susceptibility Contrast MRI is an Independent Predictor of Poor Survival in IDH-Wildtype Glioblastoma

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Authors

YPYae Won ParkSASung Soo AhnJCJong Hee Chang

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Overview

Retrospective analysis links Karnofsky status and MGMT methylation to survival in IDH-wildtype glioblastoma patients, suggesting critical roles in prognosis.

Key Points

  • To assess how tumor oxygenation imaging parameters affect overall survival in IDH-wildtype glioblastoma patients.
  • Retrospective single-institution study of 236 IDH-wildtype glioblastoma patients.
  • Extracted imaging parameters included ADC values, rCBV, CMRO2, capillary transit time heterogeneity, and oxygen extraction fraction.
  • Performed univariable and multivariable Cox analyses including clinical factors.
  • Older age, lower Karnofsky performance status, and MGMT promoter unmethylation were significantly associated with poor overall survival.
  • Multivariable analysis confirmed age, MGMT unmethylation, extent of resection, and higher CMRO2 as independent poor survival factors.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc3580f5https://doi.org/10.1093/neuonc/noaf201.1080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diffusion-weighted imaging and dynamic susceptibility contrast-enhanced perfusion-weighted imaging of the non-enhancing peritumoural region predict overall survival in glioblastoma.2026
  2. 2Diffusion-weighted imaging and dynamic susceptibility contrast-enhanced perfusion-weighted imaging of the non-enhancing peritumoural region predict overall survival in glioblastoma2026
  3. 3Contrast Enhancement Is Associated with a Higher DSC MRI-Derived Cerebral Metabolic Rate of Oxygen Index in Untreated Glioblastoma2026
  4. 4Study on the correlation between IDH gene mutation status in gliomas and metabolic parameters in 18F-FDG PET/CT2026
  5. 5RCBVmax from DSC Perfusion MRI as a Supportive Imaging Biomarker for Differentiating IDH-Mutant Astrocytomas and Oligodendroglioma2026