What question did this study set out to answer?

This research aims to determine clinical factors affecting survival outcomes in elderly patients with GBM.

November 1, 2025Neuro-OncologyOpen Access

SURG-99. Supramaximal resection and aggressive chemoradiotherapy improve survival in elderly patients with newly diagnosed supratentorial lobar IDH-wildtype glioblastoma: a single center retrospective study

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Authors

GHGuanglong Huang GYGuozhong Yi JLJinfeng Lin

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Implication

Retrospective analysis shows improved survival rates in elderly patients with GBM receiving supramaximal resection and chemoradiotherapy, pointing to critical prognostic factors.

Key Points

This research aims to determine clinical factors affecting survival outcomes in elderly patients with GBM.
Retrospective cohort analysis of 69 elderly GBM patients
Surgical resection outcomes evaluated between 2019 and 2023
Data on clinical, imaging, immunohistochemical, molecular, and postoperative treatments collected
Survival outcomes analyzed using Kaplan-Meier and Cox proportional hazards methods
Median progression-free survival (PFS) of 7.7 months and overall survival (OS) of 12.13 months reported
Higher extent of resection and TMZ chemotherapy identified as protective factors for survival
Supramaximal resection led to the longest PFS and OS compared to other treatment groups
Chemoradiotherapy significantly improved OS compared to no treatment and TMZ alone

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6925435ec0ce034ddc358161 https://doi.org/10.1093/neuonc/noaf201.1651

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Implication

Retrospective analysis shows improved survival rates in elderly patients with GBM receiving supramaximal resection and chemoradiotherapy, pointing to critical prognostic factors.

SURG-99. Supramaximal resection and aggressive chemoradiotherapy improve survival in elderly patients with newly diagnosed supratentorial lobar IDH-wildtype glioblastoma: a single center retrospective study

Discussion

Member takes

Implication

Key Points

Cite This Study

SURG-99. Supramaximal resection and aggressive chemoradiotherapy improve survival in elderly patients with newly diagnosed supratentorial lobar IDH-wildtype glioblastoma: a single center retrospective study

Discussion

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Implication

Key Points

Cite This Study

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