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The research aims to analyze the impact of maximal resection on survival outcomes in elderly glioblastoma patients.

February 11, 2026Journal of Neuro-OncologyOpen Access

Maximal resection improves survival in MGMT methylated very elderly glioblastoma patients

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Retrospective study shows maximal resection improves survival in elderly glioblastoma patients, suggesting tailored treatment approaches.

The research aims to analyze the impact of maximal resection on survival outcomes in elderly glioblastoma patients.
Conducted a single-center retrospective study of 108 patients aged ≥ 75 years
Stratified patients based on age, surgical modality, extent of resection, and MGMT status
Assessed overall survival and progression-free survival using Kaplan–Meier and Cox models.
Maximal resection improved overall survival compared to biopsy (p = 0.0047).
Maximal resection provided better overall survival than submaximal resection (p = 0.00016).
Radiochemotherapy offered the strongest survival advantage among adjuvant treatments (HR 0.174, p < 0.001).

Janković et al. (2026) studied this question.

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