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This review aims to synthesize the understanding of neuropsychiatric symptoms in Alzheimer's disease and explore management strategies.

November 1, 2025NeurotherapeuticsOpen Access

Neuropsychiatric symptoms in Alzheimer's disease: Bridging mechanisms, management, and emerging innovations

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Review reveals neuroinflammation and tau pathology influence symptom management in Alzheimer's disease, suggesting innovations in care.

This review aims to synthesize the understanding of neuropsychiatric symptoms in Alzheimer's disease and explore management strategies.
Conducted a review of biological mechanisms related to neuropsychiatric symptoms in Alzheimer's disease.
Examined treatment paradigms including pharmacologic and non-pharmacological approaches.
Highlighted emerging innovations such as digital therapeutics and neuromodulation.
Neuropsychiatric symptoms are prevalent and detrimental in Alzheimer's disease.
Current treatments show benefits but often have significant risks.
Non-pharmacological strategies like caregiver training and environmental design are underutilized and effective.

Rose et al. (2025) studied this question.

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