What question did this study set out to answer?

To evaluate the role of neuropsychiatric symptoms as early clinical indicators and potential functional biomarkers of cognitive decline in mild cognitive impairment and early Alzheimer's disease.

July 29, 2026Journal of Alzheimer s Disease

Neuropsychiatric symptoms as early clinical indicators and functional biomarkers of cognitive decline in mild cognitive impairment and early Alzheimer's disease

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DRDonna de Levante RaphaelAlzheimer's Drug Discovery Foundation

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Narrative review evaluates neuropsychiatric symptoms as early indicators of cognitive decline in mild cognitive impairment and early Alzheimer's disease, suggesting significant implications for...

Key Points

To evaluate the role of neuropsychiatric symptoms as early clinical indicators and potential functional biomarkers of cognitive decline in mild cognitive impairment and early Alzheimer's disease.
Synthesis of epidemiological, longitudinal, neuroimaging, and biomarker studies from 2012 to 2025.
Integration of findings within the mild behavioral impairment construct and AT(N) biomarker framework.
Assessment of the prevalence and impact of neuropsychiatric symptoms in different racial and ethnic groups.
Neuropsychiatric symptoms affect approximately 43–80% of individuals with mild cognitive impairment and 75–90% with early Alzheimer's disease.
Apathy, depression, anxiety, and irritability predict accelerated cognitive decline and increased caregiver burden.
Lifetime prevalence of neuropsychiatric symptoms approaches 97% across the Alzheimer's disease course.

Cite This Study

Donna de Levante Raphael (2026) studied this question.

synapsesocial.com/papers/6a69a25ec8da07d9defa5ab2 https://doi.org/10.1177/13872877261469114

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Implication

Narrative review evaluates neuropsychiatric symptoms as early indicators of cognitive decline in mild cognitive impairment and early Alzheimer's disease, suggesting significant implications for...

Neuropsychiatric symptoms as early clinical indicators and functional biomarkers of cognitive decline in mild cognitive impairment and early Alzheimer's disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Neuropsychiatric symptoms as early clinical indicators and functional biomarkers of cognitive decline in mild cognitive impairment and early Alzheimer's disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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