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November 1, 2025Neuro-OncologyOpen Access

TMOD-33. Single-cell atlas of pediatric brain tumors reveals targetable radial glia signatures in ependymoma

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Authors

SBShivani BaisiwalaMLMatthew LiKPKunal Patel.

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Overview

Single-cell RNA sequencing uncovers cellular heterogeneity in pediatric brain tumors, suggesting new therapeutic options for ependymoma and others.

Key Points

  • This research seeks to characterize pediatric brain tumors at the single-cell level to identify potential therapeutic targets.
  • Conducted single-cell RNA sequencing across various pediatric brain tumor types.
  • Mapped tumor transcriptomes to a reference atlas of the developing human brain.
  • Developed a human tumor organoid co-culture platform to model tumor growth.
  • Analyzed cellular heterogeneity and radial glia-like states in vitro.
  • Identified radial glia signatures in aggressive pediatric tumors, especially ependymoma and ATRT.
  • Confirmed PTPRZ1 expression across tumor types through immunostaining.
  • Developed a functional model to study tumor progression and therapeutic options.

Cite This Study

Baisiwala et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358397https://doi.org/10.1093/neuonc/noaf201.1907
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1METB-08. Unraveling the cellular diversity and spatial architecture of infant-type hemispheric gliomas using multi-omic profiling2025
  2. 2Abstract 6172: The transcription factor DMRTA2 regulates radial glial maintenance and tumorigenicity of pediatric high-grade glioma2026
  3. 3STEM-05. CREATING PATIENT-DERIVED TUMOROIDS TO INVESTIGATE RADIORESISTANCE IN PEDIATRIC BRAIN TUMORS2024
  4. 4Abstract IA010: Pediatric Low-Grade Gliomas Repurpose Neuron-OPC Dependencies to Control Tumor Growth2026
  5. 5ID #669 Comparative Single-Cell RNAseq Analysis Resolves Distinct Immune Microenvironments Between Pediatric Brain Tumor Types2026