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March 14, 2026Neuro-Oncology PediatricsOpen Access

METB-08. Unraveling the cellular diversity and spatial architecture of infant-type hemispheric gliomas using multi-omic profiling

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Analysis reveals transcriptomic cancer cell diversity in infant-type gliomas, suggesting RTK fusion involvement in tumorigenesis.

The study aims to explore the cellular diversity and spatial architecture of infant-type hemispheric gliomas using multi-omic profiling techniques.
Analyzed a cohort of 13 infant-type hemispheric gliomas (IHGs) with RTK fusions.
Employed single-cell multi-omic RNA/ATAC-seq and SmartSeq2 to generate over 90,000 transcriptomes.
Conducted trajectory analysis and chromatin analysis to assess cell origin and state.
Utilized MERFISH to map spatial architecture in 4 IHG samples.
Identified multiple progenitor-like cancer populations and their spatial distribution.
Highlighted the role of receptor tyrosine kinase in the early tumorigenesis stages of IHGs.
Demonstrated dynamic chromatin accessibility variations across different cell populations.

Micheli et al. (2025) studied this question.

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