What question did this study set out to answer?

To investigate how radiation-induced senescence contributes to glioblastoma recurrence.

November 1, 2025Neuro-Oncology

Csig-02. Radiation-Induced Senescence as a Driver of Glioblastoma Recurrence

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This research demonstrates that ionizing radiation promotes glioblastoma recurrence through senescence and suggests senolytic therapy for treatment.

To investigate how radiation-induced senescence contributes to glioblastoma recurrence.
Irradiated glioblastoma cell lines and patient-derived xenograft cultures to study senescence effects.
Analyzed SASP factors and JAK-STAT pathway activation in glioblastoma cells.
Explored the role of cIAP2 in senescent glioma cell survival and the effects of SMAC mimetics.
Utilized PDX and immunocompetent mouse models to assess the impact of birinapant on senescent GBM cells.
Ionizing radiation induced rapid senescence in glioblastoma cells through a p21-dependent mechanism.
Senescent glioma cells exhibited upregulation of SASP genes and activated the JAK-STAT pathway in neighboring cells.
Birinapant effectively targeted senescent glioma cells, leading to delayed tumor recurrence with low toxicity to astrocytes.

Mukherjee et al. (2025) studied this question.

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This research demonstrates that ionizing radiation promotes glioblastoma recurrence through senescence and suggests senolytic therapy for treatment.