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This review analyzes the potential of senolytics to combat glioma recurrence by targeting therapy-induced senescence and its effects on the tumor microenvironment.

April 15, 2026CancersOpen Access

The Emerging Role of Senolytics as a Next-Generation Strategy Against Glioma Recurrence: A Narrative Review

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Authors

AFAndrea FilardoHeart Failure & Transplant ICIsabella CoscarellaMagna Graecia University JBJessica BriaMagna Graecia University

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Implication

Narrative review finds senolytics may reduce glioma recurrence by targeting senescent cells, suggesting new treatment strategies.

Key Points

This review analyzes the potential of senolytics to combat glioma recurrence by targeting therapy-induced senescence and its effects on the tumor microenvironment.
Review of existing literature on glioblastoma and cellular senescence.
Analysis of the therapeutic efficacy of senolytic agents like Navitoclax, Quercetin, and Fisetin.
Discussion on the mechanisms affecting apoptosis and tumor microenvironment.
Senescent cells release factors that promote tumor recurrence and play significant roles in glioma.
Senolytic drugs effectively eliminate these senescent cells, restoring sensitivity to apoptosis.
Integrating senolytics with current therapies may improve outcomes in glioblastoma patients.

Cite This Study

Filardo et al. (2026) studied this question.

synapsesocial.com/papers/69df2b04e4eeef8a2a6aff22 https://doi.org/10.3390/cancers18081220

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The Emerging Role of Senolytics as a Next-Generation Strategy Against Glioma Recurrence: A Narrative Review

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Cite This Study

The Emerging Role of Senolytics as a Next-Generation Strategy Against Glioma Recurrence: A Narrative Review

Discussion

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Implication

Key Points

Cite This Study

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