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November 1, 2025Neuro-OncologyOpen Access

PATH-34. Assessment of BRAF alterations and recommended treatments in CNS tumors with BRAF alterations

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Authors

MOMakoto OhnoSYShunsuke YanagisawaDKDaisuke Kawauchi

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Overview

Analysis shows genomic profiling of CNS tumors with BRAF alterations, indicating low rates of matched therapy receipt.

Key Points

  • To assess the clinical utility of CGP-guided therapy for CNS tumors with BRAF alterations.
  • Reviewed CNS tumor cases with BRAF alterations registered in C-CAT from 2016 to April 2025.
  • Analyzed types of BRAF alterations and recommended treatments by expert panels.
  • Evaluated reasons for not receiving recommended therapy.
  • 267 CNS tumor cases with BRAF alterations were analyzed.
  • BRAF alterations included V600E in 59.6% of cases and fusions in 27.7%.
  • Expert panel recommended treatment in 63.3% of cases, but only 20.6% received the recommended therapy.

Cite This Study

Ohno et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358463https://doi.org/10.1093/neuonc/noaf201.0986
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