What question did this study set out to answer?

Evaluate real-world outcomes of R-MPV treatment in older patients with primary CNS lymphoma avoiding whole brain radiotherapy.

November 1, 2025Neuro-OncologyOpen Access

QOL-03. Real-world outcomes in older patients with primary CNS lymphoma treated by R-MPV treatment without whole brain radiotherapy

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Authors

HNHiroaki Nagashima KTKazuhiro Tanaka SYShunsuke Yamanishi

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Implication

Real-world outcomes show progression-free survival in elderly patients with primary CNS lymphoma treated with R-MPV, indicating potential benefits of avoiding whole brain radiotherapy.

Key Points

Evaluate real-world outcomes of R-MPV treatment in older patients with primary CNS lymphoma avoiding whole brain radiotherapy.
Evaluated patients aged ≥60 with newly diagnosed primary CNS lymphoma at Kobe University Hospital.
Analyzed outcomes based on R-MPV treatment with or without whole brain radiotherapy from 2008 to 2024.
Conducted assessments on treatment responses, survival rates, and cerebrospinal fluid examination.
Thirty-one of 40 patients achieved a complete response after R-MPV therapy.
Progression-free survival was 70.9 months for R-MPV without WBRT compared to 27.2 months with WBRT (p=0.024).
Overall survival rates were undefined for R-MPV without WBRT and 35.9 months for WBRT (p=0.0081).
Higher levels of CSF IL-10 correlated with increased ventricular volume after 1 year (p=0.0234).

Cite This Study

Nagashima et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358472 https://doi.org/10.1093/neuonc/noaf201.1505

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Implication

Real-world outcomes show progression-free survival in elderly patients with primary CNS lymphoma treated with R-MPV, indicating potential benefits of avoiding whole brain radiotherapy.

QOL-03. Real-world outcomes in older patients with primary CNS lymphoma treated by R-MPV treatment without whole brain radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

QOL-03. Real-world outcomes in older patients with primary CNS lymphoma treated by R-MPV treatment without whole brain radiotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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