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November 1, 2025American Journal of Clinical PathologyOpen Access

35 Mutational analysis of MC4R gene and body composition in a heterogeneous population: A study on obesity prevalnce

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Authors

GBGiti BayhaghiJSJeane SilvaZKZubair Karim

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Implication

Analysis reveals that obesity is linked to MC4R genetic polymorphisms and dietary intake in diverse populations.

Key Points

  • The study aims to analyze the role of MC4R gene mutations in obesity prevalence within a heterogeneous population.
  • Participants aged 18-70 from Southeastern US were genotyped for common MC4R polymorphisms.
  • Anthropometric measurements and dietary intake were assessed alongside genetic screening.
  • Data was analyzed using ANOVA, Kruskal-Wallis tests, and multivariate linear regression models.
  • Higher rates of genotype carriers were found among African Americans compared to Caucasians.
  • Increased calorie intake correlated with higher BMI and body fat percentages.
  • Participants with MC4R polymorphisms showed greater body fat and diminished fat-free mass.

Cite This Study

Bayhaghi et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc3586d5https://doi.org/10.1093/ajcp/aqaf121.350
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Also Consider

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  3. 3Assessing the Role of MC4R Gene Variants and Dietary Habits in the Development of Obesity among Adolescents2025
  4. 4Relationship between MC4R rs17782313 Polymorphism and Body Mass Index and Appetite Regulation in Young Adults in Indonesia2025 · 1 citations
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